Featured Projects

Identification of cellular junctions acquired using Operetta CLS, as reported in Integrated Multiparametric High-Content Profiling of Endothelial Cells.  Wiseman E, Zamuner A, Tang Z, Rogers J, Munir S, Di Silvio L, Danovi D, Veschini L. SLAS Discov. 2019 Mar;24(3):264-273. doi: 10.1177/2472555218820848. Epub 2019 Jan 25.


2-D 

iPSC derived endothelial cells

iPSC-ECFC (Endothelial cell-forming colonies derived from induced pluripotent stem cells) treated with VEGF. 

Imaged with Operetta CLS 40x Water Immersion Objective.  Nuclei (Hoechst), cell junctions (594) and spots (488).

Image courtesy Lorenzo Veschini


2.5-D

iPSC cultured on micro patterns

Recapitulating embryonic development in vitro using human induced pluripotent stem cells. Cells confined in space are exposed to morphogens mirroring early development.

Imaged with Operetta CLS 40x Water Immersion Objective. Differentiation markers stained in different colours.

Image courtesy Alice Vickers

3-D

iPSC embedded in microenvironments

Self-patterning of human induced pluripotent stem cells exposed to different media and gels condition determine consistent symmetry breakage and differentiation.

Imaged with JuLI Stage.

Image courtesy Haneen Alsehli


Image courtesy of Jennifer Coleman, Ph.D Student